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- B1df293e15735fcec1d9eb12f55233b1d NCIT_P378 "KEGG" @default.
- B1df293e15735fcec1d9eb12f55233b1d type Axiom @default.
- B1df293e15735fcec1d9eb12f55233b1d annotatedProperty NCIT_P325 @default.
- B1df293e15735fcec1d9eb12f55233b1d annotatedSource NCIT_C91440 @default.
- B1df293e15735fcec1d9eb12f55233b1d annotatedTarget "Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy." @default.