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- B1e590debcae4d1d2338c2c1eab9ae6ec NCIT_P378 "NCI" @default.
- B1e590debcae4d1d2338c2c1eab9ae6ec type Axiom @default.
- B1e590debcae4d1d2338c2c1eab9ae6ec annotatedProperty IAO_0000115 @default.
- B1e590debcae4d1d2338c2c1eab9ae6ec annotatedSource NCIT_C2570 @default.
- B1e590debcae4d1d2338c2c1eab9ae6ec annotatedTarget "A compound composed of the short chain fatty acid (SCFA) butyrate combined with the amino acid arginine, with potential Epstein-Barr virus thymidine kinase gene (EBV-TK)-inducing activity. Upon administration, arginine butyrate induces the expression of thymidine kinase (TK). This activates a co-administered antiviral, such as ganciclovir, and results in the destruction of EBV-infected cancer cells. In addition, butyrate inhibits histone deacetylase (HDAC), which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis." @default.