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- B1ec9277bc0ef061170ca751cea33ae40 NCIT_P378 "NCI" @default.
- B1ec9277bc0ef061170ca751cea33ae40 type Axiom @default.
- B1ec9277bc0ef061170ca751cea33ae40 annotatedProperty IAO_0000115 @default.
- B1ec9277bc0ef061170ca751cea33ae40 annotatedSource NCIT_C180826 @default.
- B1ec9277bc0ef061170ca751cea33ae40 annotatedTarget "An inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon administration, HIF-2alpha inhibitor DFF332 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors." @default.