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- B1ed2305f887203f5199c16eba09ca57c NCIT_P378 "NCI" @default.
- B1ed2305f887203f5199c16eba09ca57c type Axiom @default.
- B1ed2305f887203f5199c16eba09ca57c annotatedProperty IAO_0000115 @default.
- B1ed2305f887203f5199c16eba09ca57c annotatedSource NCIT_C180911 @default.
- B1ed2305f887203f5199c16eba09ca57c annotatedTarget "An inhaled formulation of the endogenous cytokine human interferon (IFN) beta-1a, with potential antiviral and immunomodulating activities. Administrated through inhalation of the nebulized solution, SNG001 targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1a is produced following viral infection and it plays a key role in innate immune response against viral pathogens." @default.