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- B1edb8b4e431672bdf717964c5551ba54 NCIT_P378 "NCI" @default.
- B1edb8b4e431672bdf717964c5551ba54 type Axiom @default.
- B1edb8b4e431672bdf717964c5551ba54 annotatedProperty IAO_0000115 @default.
- B1edb8b4e431672bdf717964c5551ba54 annotatedSource NCIT_C47546 @default.
- B1edb8b4e431672bdf717964c5551ba54 annotatedTarget "The hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse." @default.