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- B1ee88df82efd3129513c60b87c016d69 NCIT_P378 "NCI" @default.
- B1ee88df82efd3129513c60b87c016d69 type Axiom @default.
- B1ee88df82efd3129513c60b87c016d69 annotatedProperty IAO_0000115 @default.
- B1ee88df82efd3129513c60b87c016d69 annotatedSource NCIT_C1271 @default.
- B1ee88df82efd3129513c60b87c016d69 annotatedTarget "A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)" @default.