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- B1ef3ab9b370e26bf07390441c976bbbd NCIT_P378 "NCI" @default.
- B1ef3ab9b370e26bf07390441c976bbbd type Axiom @default.
- B1ef3ab9b370e26bf07390441c976bbbd annotatedProperty IAO_0000115 @default.
- B1ef3ab9b370e26bf07390441c976bbbd annotatedSource NCIT_C166608 @default.
- B1ef3ab9b370e26bf07390441c976bbbd annotatedTarget "An orally bioavailable inhibitor of the innate immune signaling sensor nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD containing protein 3; NALP3), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, dapansutrile specifically binds to and inhibits NLRP3, the sensor component of the NLRP3 inflammasome, and prevents the formation of the NLRP3 inflammasome. This inhibits the production of the pro-inflammatory cytokines interleukin-1-beta (IL-1beta) and interleukin-18 (IL-18), which may prevent or reduce inflammation. NLRP3 plays an important role in immunity and inflammation." @default.