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- B1f142b3cc3ff1d1171b31af2e25ba8d0 NCIT_P378 "NCI" @default.
- B1f142b3cc3ff1d1171b31af2e25ba8d0 type Axiom @default.
- B1f142b3cc3ff1d1171b31af2e25ba8d0 annotatedProperty IAO_0000115 @default.
- B1f142b3cc3ff1d1171b31af2e25ba8d0 annotatedSource NCIT_C1244 @default.
- B1f142b3cc3ff1d1171b31af2e25ba8d0 annotatedTarget "A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)" @default.