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- B1f6f133c0328ef309d7fbb12e76c638c NCIT_P378 "NCI" @default.
- B1f6f133c0328ef309d7fbb12e76c638c type Axiom @default.
- B1f6f133c0328ef309d7fbb12e76c638c annotatedProperty IAO_0000115 @default.
- B1f6f133c0328ef309d7fbb12e76c638c annotatedSource NCIT_C2267 @default.
- B1f6f133c0328ef309d7fbb12e76c638c annotatedTarget "A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters." @default.