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- B1fb0d6c8e968ce6cbd6c0b0dc15e523c NCIT_P378 "NCI" @default.
- B1fb0d6c8e968ce6cbd6c0b0dc15e523c type Axiom @default.
- B1fb0d6c8e968ce6cbd6c0b0dc15e523c annotatedProperty IAO_0000115 @default.
- B1fb0d6c8e968ce6cbd6c0b0dc15e523c annotatedSource NCIT_C65274 @default.
- B1fb0d6c8e968ce6cbd6c0b0dc15e523c annotatedTarget "The hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting." @default.