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- B1fb7de70df75fd6167d1d8cfee271a3c NCIT_P378 "NCI" @default.
- B1fb7de70df75fd6167d1d8cfee271a3c type Axiom @default.
- B1fb7de70df75fd6167d1d8cfee271a3c annotatedProperty IAO_0000115 @default.
- B1fb7de70df75fd6167d1d8cfee271a3c annotatedSource NCIT_C187658 @default.
- B1fb7de70df75fd6167d1d8cfee271a3c annotatedTarget "A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CLDN18.2/anti-CD3 bispecific antibody ASP2138 simultaneously binds to both CLDN18.2-expressing tumor cells and CD3-expressing T-cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.