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- B2028e855897fd750084e86481a31a8e0 NCIT_P378 "NCI" @default.
- B2028e855897fd750084e86481a31a8e0 type Axiom @default.
- B2028e855897fd750084e86481a31a8e0 annotatedProperty IAO_0000115 @default.
- B2028e855897fd750084e86481a31a8e0 annotatedSource NCIT_C1268 @default.
- B2028e855897fd750084e86481a31a8e0 annotatedTarget "An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis." @default.