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- B2034e90532797ad84e3a876e90e5ff02 NCIT_P378 "NCI" @default.
- B2034e90532797ad84e3a876e90e5ff02 type Axiom @default.
- B2034e90532797ad84e3a876e90e5ff02 annotatedProperty IAO_0000115 @default.
- B2034e90532797ad84e3a876e90e5ff02 annotatedSource NCIT_C380 @default.
- B2034e90532797ad84e3a876e90e5ff02 annotatedTarget "An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure." @default.