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- B213ffb347e14dd6a6d484f0a363ce7a9 NCIT_P378 "NCI" @default.
- B213ffb347e14dd6a6d484f0a363ce7a9 type Axiom @default.
- B213ffb347e14dd6a6d484f0a363ce7a9 annotatedProperty IAO_0000115 @default.
- B213ffb347e14dd6a6d484f0a363ce7a9 annotatedSource NCIT_C2344 @default.
- B213ffb347e14dd6a6d484f0a363ce7a9 annotatedTarget "The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)" @default.