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- B21598d9097cb715b425bc4ee7e7ddb3c NCIT_P378 "NCI" @default.
- B21598d9097cb715b425bc4ee7e7ddb3c type Axiom @default.
- B21598d9097cb715b425bc4ee7e7ddb3c annotatedProperty IAO_0000115 @default.
- B21598d9097cb715b425bc4ee7e7ddb3c annotatedSource NCIT_C29854 @default.
- B21598d9097cb715b425bc4ee7e7ddb3c annotatedTarget "The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)" @default.