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- B2198d763777a8fe87e588e39f18b35eb NCIT_P378 "NCI" @default.
- B2198d763777a8fe87e588e39f18b35eb type Axiom @default.
- B2198d763777a8fe87e588e39f18b35eb annotatedProperty IAO_0000115 @default.
- B2198d763777a8fe87e588e39f18b35eb annotatedSource NCIT_C61645 @default.
- B2198d763777a8fe87e588e39f18b35eb annotatedTarget "A carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.