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- B21c49fae8f20c52415e4aa33d9f4ab77 NCIT_P378 "NCI" @default.
- B21c49fae8f20c52415e4aa33d9f4ab77 type Axiom @default.
- B21c49fae8f20c52415e4aa33d9f4ab77 annotatedProperty IAO_0000115 @default.
- B21c49fae8f20c52415e4aa33d9f4ab77 annotatedSource NCIT_C519 @default.
- B21c49fae8f20c52415e4aa33d9f4ab77 annotatedTarget "A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses." @default.