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- B21ecb3e2b8e1c5c60072a6fb6be00c59 NCIT_P378 "NCI" @default.
- B21ecb3e2b8e1c5c60072a6fb6be00c59 type Axiom @default.
- B21ecb3e2b8e1c5c60072a6fb6be00c59 annotatedProperty IAO_0000115 @default.
- B21ecb3e2b8e1c5c60072a6fb6be00c59 annotatedSource NCIT_C97555 @default.
- B21ecb3e2b8e1c5c60072a6fb6be00c59 annotatedTarget "The sodium salt of leucovorin, an active metabolite of folic acid, used as an antidote to folic acid antagonists. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonists and counteracts the toxic effects of these drugs. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. In comparison with the calcium salt, sodium salt does not form precipitate when mixed other folate antagonists." @default.