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- B2292968b90f4ee65edd6e840b545cb0c NCIT_P378 "NCI" @default.
- B2292968b90f4ee65edd6e840b545cb0c type Axiom @default.
- B2292968b90f4ee65edd6e840b545cb0c annotatedProperty IAO_0000115 @default.
- B2292968b90f4ee65edd6e840b545cb0c annotatedSource NCIT_C1855 @default.
- B2292968b90f4ee65edd6e840b545cb0c annotatedTarget "An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04)" @default.