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- B22db4b4800a3d4ea12cf32d9d5342920 NCIT_P378 "NCI" @default.
- B22db4b4800a3d4ea12cf32d9d5342920 type Axiom @default.
- B22db4b4800a3d4ea12cf32d9d5342920 annotatedProperty IAO_0000115 @default.
- B22db4b4800a3d4ea12cf32d9d5342920 annotatedSource NCIT_C175940 @default.
- B22db4b4800a3d4ea12cf32d9d5342920 annotatedTarget "An orally bioavailable, amorphous solid dispersion formulation of the steroidal compound abiraterone, with potential antiandrogen activity. Upon oral administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This may suppress testosterone production by both the testes and the adrenals to castrate-range levels." @default.