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- B22ea2abeacf65ab1f216e69ff4544891 NCIT_P378 "NCI" @default.
- B22ea2abeacf65ab1f216e69ff4544891 type Axiom @default.
- B22ea2abeacf65ab1f216e69ff4544891 annotatedProperty IAO_0000115 @default.
- B22ea2abeacf65ab1f216e69ff4544891 annotatedSource NCIT_C52196 @default.
- B22ea2abeacf65ab1f216e69ff4544891 annotatedTarget "An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth." @default.