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- B2321cef6194fca6f32e78db26a29462c NCIT_P378 "NCI" @default.
- B2321cef6194fca6f32e78db26a29462c type Axiom @default.
- B2321cef6194fca6f32e78db26a29462c annotatedProperty IAO_0000115 @default.
- B2321cef6194fca6f32e78db26a29462c annotatedSource NCIT_C29454 @default.
- B2321cef6194fca6f32e78db26a29462c annotatedTarget "A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.