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- B23d4d0aaf35a1919199567ae962a2cee NCIT_P378 "NCI" @default.
- B23d4d0aaf35a1919199567ae962a2cee type Axiom @default.
- B23d4d0aaf35a1919199567ae962a2cee annotatedProperty IAO_0000115 @default.
- B23d4d0aaf35a1919199567ae962a2cee annotatedSource NCIT_C61615 @default.
- B23d4d0aaf35a1919199567ae962a2cee annotatedTarget "A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria." @default.