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- B2400afb7ecde0543858c98e57174a8d7 NCIT_P378 "NCI" @default.
- B2400afb7ecde0543858c98e57174a8d7 type Axiom @default.
- B2400afb7ecde0543858c98e57174a8d7 annotatedProperty IAO_0000115 @default.
- B2400afb7ecde0543858c98e57174a8d7 annotatedSource NCIT_C62042 @default.
- B2400afb7ecde0543858c98e57174a8d7 annotatedTarget "A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.