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- B24930c99834c031fd6c0828d6d5cf746 NCIT_P378 "NCI" @default.
- B24930c99834c031fd6c0828d6d5cf746 type Axiom @default.
- B24930c99834c031fd6c0828d6d5cf746 annotatedProperty IAO_0000115 @default.
- B24930c99834c031fd6c0828d6d5cf746 annotatedSource NCIT_C973 @default.
- B24930c99834c031fd6c0828d6d5cf746 annotatedTarget "The sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced." @default.