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- B24c59cec0eb6f5d69ff904daec3c3db1 NCIT_P378 "BIOCARTA" @default.
- B24c59cec0eb6f5d69ff904daec3c3db1 type Axiom @default.
- B24c59cec0eb6f5d69ff904daec3c3db1 annotatedProperty NCIT_P325 @default.
- B24c59cec0eb6f5d69ff904daec3c3db1 annotatedSource NCIT_C39191 @default.
- B24c59cec0eb6f5d69ff904daec3c3db1 annotatedTarget "The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (This definition may be outdated - see the DesignNote.)" @default.