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- B257eeb4faaff62ffaa6f72e40f66872b NCIT_P378 "NCI" @default.
- B257eeb4faaff62ffaa6f72e40f66872b type Axiom @default.
- B257eeb4faaff62ffaa6f72e40f66872b annotatedProperty IAO_0000115 @default.
- B257eeb4faaff62ffaa6f72e40f66872b annotatedSource NCIT_C29146 @default.
- B257eeb4faaff62ffaa6f72e40f66872b annotatedTarget "A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects." @default.