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- B25e8b7fa9031df5e88e7add1dd3fe90b NCIT_P378 "NCI" @default.
- B25e8b7fa9031df5e88e7add1dd3fe90b type Axiom @default.
- B25e8b7fa9031df5e88e7add1dd3fe90b annotatedProperty IAO_0000115 @default.
- B25e8b7fa9031df5e88e7add1dd3fe90b annotatedSource NCIT_C103857 @default.
- B25e8b7fa9031df5e88e7add1dd3fe90b annotatedTarget "A IgM monoclonal antibody (MoAb) against 78-kDa glucose-regulated protein (GRP78; also called BiP or HSPA5), with potential proapoptotic and antineoplastic activities. Upon intravenous administration of the anti-GRP78 monoclonal antibody PAT-SM6, the MoAb strongly binds to GRP78, thereby preventing the activation of multiple GRP78-mediated pathways and blocking the GRP78-induced suppression of apoptotic pathways. This eventually leads to the induction of tumor cell apoptosis and a reduction in tumor cell proliferation. GRP78, the endoplasmic reticulum (ER) chaperone and unfolded protein response (UPR) regulator, is overexpressed on the surface of a variety of cancer cell types; its expression is associated with increased tumor cell survival and proliferation, as well as angiogenesis and resistance to chemotherapy." @default.