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- B264502204d085106ed596088a74f8e29 NCIT_P378 "NCI" @default.
- B264502204d085106ed596088a74f8e29 type Axiom @default.
- B264502204d085106ed596088a74f8e29 annotatedProperty IAO_0000115 @default.
- B264502204d085106ed596088a74f8e29 annotatedSource NCIT_C102854 @default.
- B264502204d085106ed596088a74f8e29 annotatedTarget "A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Efbemalenograstim alfa binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy." @default.