Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B2657ef7063af8b2ed87f153a9b05a02c> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B2657ef7063af8b2ed87f153a9b05a02c NCIT_P378 "NCI" @default.
- B2657ef7063af8b2ed87f153a9b05a02c type Axiom @default.
- B2657ef7063af8b2ed87f153a9b05a02c annotatedProperty IAO_0000115 @default.
- B2657ef7063af8b2ed87f153a9b05a02c annotatedSource NCIT_C65229 @default.
- B2657ef7063af8b2ed87f153a9b05a02c annotatedTarget "A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections." @default.