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- B26ba76912e4b79d5e255d3419913c3af NCIT_P378 "NCI" @default.
- B26ba76912e4b79d5e255d3419913c3af type Axiom @default.
- B26ba76912e4b79d5e255d3419913c3af annotatedProperty IAO_0000115 @default.
- B26ba76912e4b79d5e255d3419913c3af annotatedSource NCIT_C557 @default.
- B26ba76912e4b79d5e255d3419913c3af annotatedTarget "A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum." @default.