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- B26e375eda161ac65dfab84caadb7efcf NCIT_P378 "NCI" @default.
- B26e375eda161ac65dfab84caadb7efcf type Axiom @default.
- B26e375eda161ac65dfab84caadb7efcf annotatedProperty IAO_0000115 @default.
- B26e375eda161ac65dfab84caadb7efcf annotatedSource NCIT_C1181 @default.
- B26e375eda161ac65dfab84caadb7efcf annotatedTarget "An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)" @default.