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- B275bb5d9878fab644ebbd7894eb7ab1c NCIT_P378 "NCI" @default.
- B275bb5d9878fab644ebbd7894eb7ab1c type Axiom @default.
- B275bb5d9878fab644ebbd7894eb7ab1c annotatedProperty IAO_0000115 @default.
- B275bb5d9878fab644ebbd7894eb7ab1c annotatedSource NCIT_C52906 @default.
- B275bb5d9878fab644ebbd7894eb7ab1c annotatedTarget "Human PTEN wild type allele is located in the vicinity of 10q23.3 and is approximately 109 kb in length. This allele, which encodes phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN protein, plays a role in multiple signal transduction pathways. The wild-type allele influences cellular proliferation, survival, adhesion, migration and cell cycle progression through the modulation of the phosphorylation state of both phosphoinositides and focal adhesion kinase. Mutated forms of the gene are found in a large number of cancers." @default.