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- B27a03e9a12347a9faf227a0fc4a45f93 NCIT_P378 "NCI" @default.
- B27a03e9a12347a9faf227a0fc4a45f93 type Axiom @default.
- B27a03e9a12347a9faf227a0fc4a45f93 annotatedProperty IAO_0000115 @default.
- B27a03e9a12347a9faf227a0fc4a45f93 annotatedSource NCIT_C1855 @default.
- B27a03e9a12347a9faf227a0fc4a45f93 annotatedTarget "An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04)" @default.