Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B27fdae2bd1f957ea64235a81c551dfb0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B27fdae2bd1f957ea64235a81c551dfb0 NCIT_P378 "NCI" @default.
- B27fdae2bd1f957ea64235a81c551dfb0 type Axiom @default.
- B27fdae2bd1f957ea64235a81c551dfb0 annotatedProperty IAO_0000115 @default.
- B27fdae2bd1f957ea64235a81c551dfb0 annotatedSource NCIT_C151951 @default.
- B27fdae2bd1f957ea64235a81c551dfb0 annotatedTarget "An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, trotabresib preferentially binds to the second bromodomain (BD2) of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that contain two homologous bromodomains, the BD1 and BD2 domains. They play an important role during development and cellular growth." @default.