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- B280799faffddcf8841f57ae0564e726c NCIT_P378 "NCI" @default.
- B280799faffddcf8841f57ae0564e726c type Axiom @default.
- B280799faffddcf8841f57ae0564e726c annotatedProperty IAO_0000115 @default.
- B280799faffddcf8841f57ae0564e726c annotatedSource NCIT_C627 @default.
- B280799faffddcf8841f57ae0564e726c annotatedTarget "The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties." @default.