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- B2844f9015c41f86c1da12993b370b39e NCIT_P378 "NCI" @default.
- B2844f9015c41f86c1da12993b370b39e type Axiom @default.
- B2844f9015c41f86c1da12993b370b39e annotatedProperty IAO_0000115 @default.
- B2844f9015c41f86c1da12993b370b39e annotatedSource NCIT_C560 @default.
- B2844f9015c41f86c1da12993b370b39e annotatedTarget "A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)" @default.