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- B2884937a4701614d6f59a16f73ee83fa NCIT_P378 "NCI" @default.
- B2884937a4701614d6f59a16f73ee83fa type Axiom @default.
- B2884937a4701614d6f59a16f73ee83fa annotatedProperty IAO_0000115 @default.
- B2884937a4701614d6f59a16f73ee83fa annotatedSource NCIT_C18909 @default.
- B2884937a4701614d6f59a16f73ee83fa annotatedTarget "Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss of regulation of the gene product, and predisposing the cell to neoplastic transformation. Proto-oncogenes are ordinarilly involved in transduction of signals that regulate cell growth and differentiation. Activation of such genes overrides the normal mechanisms of regulation and is an important step in the process of cellular transformation." @default.