Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B288b1baf2d1d7ce5d5f7154cafcd0069> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B288b1baf2d1d7ce5d5f7154cafcd0069 NCIT_P378 "NCI" @default.
- B288b1baf2d1d7ce5d5f7154cafcd0069 type Axiom @default.
- B288b1baf2d1d7ce5d5f7154cafcd0069 annotatedProperty IAO_0000115 @default.
- B288b1baf2d1d7ce5d5f7154cafcd0069 annotatedSource NCIT_C115969 @default.
- B288b1baf2d1d7ce5d5f7154cafcd0069 annotatedTarget "A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells." @default.