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- B293447872eaa6899da96f175fe495f95 NCIT_P378 "NCI" @default.
- B293447872eaa6899da96f175fe495f95 type Axiom @default.
- B293447872eaa6899da96f175fe495f95 annotatedProperty IAO_0000115 @default.
- B293447872eaa6899da96f175fe495f95 annotatedSource NCIT_C123722 @default.
- B293447872eaa6899da96f175fe495f95 annotatedTarget "An orally available, irreversible inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, Hemay022 covalently binds to and inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.