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- B293efaf8c5370a53f8a27c59e5c32c27 NCIT_P378 "NCI" @default.
- B293efaf8c5370a53f8a27c59e5c32c27 type Axiom @default.
- B293efaf8c5370a53f8a27c59e5c32c27 annotatedProperty IAO_0000115 @default.
- B293efaf8c5370a53f8a27c59e5c32c27 annotatedSource NCIT_C61869 @default.
- B293efaf8c5370a53f8a27c59e5c32c27 annotatedTarget "A broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth." @default.