Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B29a5ebcb38912e568e7da789b4d8d66a> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B29a5ebcb38912e568e7da789b4d8d66a NCIT_P378 "NCI" @default.
- B29a5ebcb38912e568e7da789b4d8d66a type Axiom @default.
- B29a5ebcb38912e568e7da789b4d8d66a annotatedProperty IAO_0000115 @default.
- B29a5ebcb38912e568e7da789b4d8d66a annotatedSource NCIT_C95710 @default.
- B29a5ebcb38912e568e7da789b4d8d66a annotatedTarget "An antibody-drug conjugate (ADC) containing labetuzumab, a mildly reduced, anti-CEACAM5 humanized monoclonal antibody, conjugated to the potent topoisomerase I inhibitor SN-38, with antineoplastic activity. The monoclonal antibody moiety of labetuzumab govitecan selectively binds to carcinoembryonic cell adhesion molecule 5 (CEACAM5), which is abundantly expressed on the surface of a majority of solid tumors. Upon internalization and proteolytic cleavage, SN-38, the active metabolite of irinotecan, inhibits the activity of topoisomerase I in the tumor cells, eventually inhibiting both DNA replication and transcription and leading to tumor cell apoptosis." @default.