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- B2a3741e09b3caf1cc91deb64cc77ebb0 NCIT_P378 "NCI" @default.
- B2a3741e09b3caf1cc91deb64cc77ebb0 type Axiom @default.
- B2a3741e09b3caf1cc91deb64cc77ebb0 annotatedProperty IAO_0000115 @default.
- B2a3741e09b3caf1cc91deb64cc77ebb0 annotatedSource NCIT_C1319 @default.
- B2a3741e09b3caf1cc91deb64cc77ebb0 annotatedTarget "The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.