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- B2a3f1c41ec34ea58da0d3e242ca7e3ae NCIT_P378 "NCI" @default.
- B2a3f1c41ec34ea58da0d3e242ca7e3ae type Axiom @default.
- B2a3f1c41ec34ea58da0d3e242ca7e3ae annotatedProperty IAO_0000115 @default.
- B2a3f1c41ec34ea58da0d3e242ca7e3ae annotatedSource NCIT_C898 @default.
- B2a3f1c41ec34ea58da0d3e242ca7e3ae annotatedTarget "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04)" @default.