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- B2a465a28570b17685c48c2dbf896339f NCIT_P378 "NCI" @default.
- B2a465a28570b17685c48c2dbf896339f type Axiom @default.
- B2a465a28570b17685c48c2dbf896339f annotatedProperty IAO_0000115 @default.
- B2a465a28570b17685c48c2dbf896339f annotatedSource NCIT_C2654 @default.
- B2a465a28570b17685c48c2dbf896339f annotatedTarget "A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system." @default.