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- B2a4d8da5bdfdf420d05ce0dc8bdeec3d NCIT_P378 "NCI" @default.
- B2a4d8da5bdfdf420d05ce0dc8bdeec3d type Axiom @default.
- B2a4d8da5bdfdf420d05ce0dc8bdeec3d annotatedProperty IAO_0000115 @default.
- B2a4d8da5bdfdf420d05ce0dc8bdeec3d annotatedSource NCIT_C103828 @default.
- B2a4d8da5bdfdf420d05ce0dc8bdeec3d annotatedTarget "A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteasomal degradation, through an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses." @default.