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- B2bafbf7dae0a608a859e3662c08bc155 NCIT_P378 "NCI" @default.
- B2bafbf7dae0a608a859e3662c08bc155 type Axiom @default.
- B2bafbf7dae0a608a859e3662c08bc155 annotatedProperty IAO_0000115 @default.
- B2bafbf7dae0a608a859e3662c08bc155 annotatedSource NCIT_C62765 @default.
- B2bafbf7dae0a608a859e3662c08bc155 annotatedTarget "An orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and colony stimulating factor 1 receptor (CSF1R) tyrosine kinases, which may result in the induction of endothelial cell apoptosis, the reduction in tumor vasculature, the inhibition of tumor cell proliferation and migration, and antifibrotic activity in pulmonary fibrosis. In addition, nintedanib also binds to and inhibits members of the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like tyrosine kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor angiogenesis, tumor cell proliferation and metastasis, as well as pulmonary fibrosis." @default.