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- B2bb5c301cecf412ed10dcf528865ec28 NCIT_P378 "BIOCARTA" @default.
- B2bb5c301cecf412ed10dcf528865ec28 type Axiom @default.
- B2bb5c301cecf412ed10dcf528865ec28 annotatedProperty NCIT_P325 @default.
- B2bb5c301cecf412ed10dcf528865ec28 annotatedSource NCIT_C39169 @default.
- B2bb5c301cecf412ed10dcf528865ec28 annotatedTarget "Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. (This definition may be outdated - see the DesignNote.)" @default.