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- B2be1f1f5fabbfb05cce742e8e61431b7 NCIT_P378 "KEGG" @default.
- B2be1f1f5fabbfb05cce742e8e61431b7 type Axiom @default.
- B2be1f1f5fabbfb05cce742e8e61431b7 annotatedProperty NCIT_P325 @default.
- B2be1f1f5fabbfb05cce742e8e61431b7 annotatedSource NCIT_C91473 @default.
- B2be1f1f5fabbfb05cce742e8e61431b7 annotatedTarget "Endocytosis is a mechanism for cells to remove ligands, nutrients, plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type." @default.