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- B2bed2f885c476f419c5c079d7992dabc NCIT_P378 "NCI" @default.
- B2bed2f885c476f419c5c079d7992dabc type Axiom @default.
- B2bed2f885c476f419c5c079d7992dabc annotatedProperty IAO_0000115 @default.
- B2bed2f885c476f419c5c079d7992dabc annotatedSource NCIT_C1877 @default.
- B2bed2f885c476f419c5c079d7992dabc annotatedTarget "A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins." @default.